Efficacy and Side Effects of the Regional Arterial Infusion of Anti-Cancer Drugs Combined with Direct Hemoperfusion in Malignancies of the Urinary Tract

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Abstract
Regional arterial infusion of high doses of anti-cancer drugs combined with direct hemoperfusion was done in 12 patients with malignancies of the urinary tract. The perfuser contained 130 g activated charcoal, which was coated with cellulose. General toxicity caused by escape of the drug from the tumor area was prevented by adsorption within activated charcoal. The capacity of activated charcoal to adsorb doxorubicin hydrochloride was excellent, as determined by measurements of plasma concentration. With this method, objective tumor reduction was noted in 84% of the patients with prostatic or bladder carcinoma, although results were disappointing in patients with renal cell carcinoma.