Pharmacology and Treatment Maintenance treatment of psoriasis by Tigason: a double-blind randomized clinical trial

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Abstract
Extensive lesions on 36 patients with psoriasis were treated by Tigason, 1 mg/kg/day plus PUVA until skin clearance. A clinical score was calculated for each body area, and erythema, scaling, thickness and pruritus of the lesions were scored from 0 to 3. Skin clearing was defined as a clinical score 50% of the initial score. Among the 36 patients randomized, 20 received placebo and 16 received Tigason. Relapses increased quickly in the patients on placebo, but occurred in few patients treated by Tigason with 60% remaining clear after 1 year (P<0.05). Surprisingly, the kinetics of disappearance of the most frequent side effect, cheilitis, was the same in the Tigason group and in the placebo group. This double‐blind randomized clinical trial shows that Tigason at low doses is an efficient and well‐tolerated maintenance treatment of psoriasis.