Genetic transmission of hyper-responsivity in crosses between spontaneously hypertensive and Wistar-Kyoto rats
- 1 December 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Journal Of Hypertension
- Vol. 6 (4) , S52-54
- https://doi.org/10.1097/00004872-198812040-00012
Abstract
Cardiovascular and behavioural responses to alerting stimuli (100 ms air puff) are exaggerated in spontaneously hypertensive rats (SHR). Wistar—Kyoto rats (WKY) exhibit bradycardia accompanying a startle-induced pressor response, whereas SHR demonstrate tachycardia. This study was designed to determine whether hyper-responsivity to startle is genetically linked to hypertension in SHR. An F1-generation, bred from SHR males and WKY females, demonstrated motor and cardiovascular responsiveness not different from WKY parents. Brother-sister mating of F1-animals produced an F2-generation with widely distributed blood pressures. Segregation of F2 by systolic blood pressure (>180 or 2 group with elevated arterial pressure exhibited tachycardia to startle that was similar to SHR grandparents. The heart rate response to acute stress may therefore serve as a more reliable genetic marker for hypertension than either the behavioural or blood pressure response, and apparently shares close genetic linkage with the hypertension.Keywords
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