Translating the Results of Randomized Trials into Clinical Practice

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Abstract
Background and Purpose— Numerous studies have documented under use of warfarin particularly among elderly patients. A better understanding of the discrepancy between trials and clinical practice will help inform stroke prevention strategies in this vulnerable age group. The study objective was to prospectively assess the use of antithrombotic therapy among a contemporary cohort of patients with atrial fibrillation at the time of hospital discharge. In addition to baseline characteristics, we sought to define the physician-cited reason for not prescribing warfarin for each patient. Methods— Patients with atrial fibrillation were prospectively identified and followed to hospital discharge. Enrolled patients were ≥65 years of age, not taking warfarin on admission, and had their longitudinal care provided at our institution. Predictors of warfarin use were determined and physician-cited contraindications were compared across age groups. Results— Fifty-one percent (n=206) of patients were discharged on warfari...