Effect of Diet on Rate of Alcohol Oxidation by the Liver.

Abstract
Weanling rat liver homogenate had about 1/2 the level of alcohol oxidation activity eventually achieved by adult rats on a chow diet (net O2 uptake of 24 cmm./10 min./200 mg. fresh liver for the adult normal rat). 85% or 75% respectively of this normal level of activity was reached by feeding chow or a purified 24% casein diet for 2 wks. A protein-free diet removed about 85% of this enzymatic activity from the liver. Adult rats responded similarly to these diets. Complete starvation for 7 days reduced this activity about 50%, while a 50% food restriction for 2 wks. gave less than a 20% decrease in the rate of alcohol oxidation.

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