Individualized selection of antihypertensive drug therapy for older patients.

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Abstract
As is widely known and discussed, The Fifth Report of the Joint National Committee (JNC V)1 suggested that diuretics and β-blockers were the usually preferred first-line therapy because they had been found to lower morbidity and mortality. These were the drugs used in the long-term randomized clinical trials that had a demonstrated reduction of cardiovascular events.2–5 It should be emphasized that the newer drugs were also effective in lowering blood pressure; however, ethical considerations (inability to use placebo once effective treatment has been demonstrated) prevented their being tested in the same way as the earlier drugs.

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