The use of glycylhistidyllysine in culture systems
- 1 June 1981
- journal article
- review article
- Published by Springer Nature in In Vitro Cellular & Developmental Biology - Plant
- Vol. 17 (6) , 459-466
- https://doi.org/10.1007/bf02633506
Abstract
Glycylhistidyllysine (GHL), a tripeptide isolated from plasma, has been shown to alter the growth rate of many cell types and organisms in culture systems. The tripeptide is optimally active at concentrations between 10 and 200 ng/ml. Some of the more interesting uses of GHL are highlighted in this paper. Present information suggests that GHL functions as a transporter of transition metals, in particular copper, to the cell surface for up-take into the cell.Keywords
This publication has 27 references indexed in Scilit:
- Growth‐modulating tripeptide (glycylhistidyllysine): Associaton with copper and iron in plasma, and stimulation of adhesiveness and growth of hepatoma cells in culture by tripeptide‐metal ion complexesJournal of Cellular Physiology, 1980
- Growth-modulating human plasma tripeptide: Relationship between molecular structure and DNA synthesis in hepatoma cellsFEBS Letters, 1979
- Release of plasminogen activator from normal and neoplastic endometriumCellular and Molecular Life Sciences, 1979
- Freeze-fracture study of immune-induced Schistosoma mansoni membrane alterationsJournal of Ultrastructure Research, 1979
- Organ cultures of human fetal hepatocytes in the study of extra- and intracellular α1-antitrypsinBiochimica et Biophysica Acta (BBA) - General Subjects, 1978
- Inhibition of lymphocyte proliferation by factor(s) produced by Schistosoma mansoniEuropean Journal of Immunology, 1977
- Development of larvae of Ascaris suum from the third to the fourth stage in a chemically defined mediumInternational Journal for Parasitology, 1977
- Growth-modulating serum tripeptide is glycyl-histidyl-lysineCellular and Molecular Life Sciences, 1977
- The Cell Growth-Promoting FactorHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1975
- A synthetic tripeptide which increases survival of normal liver cells, and stimulates growth in hepatoma cellsBiochemical and Biophysical Research Communications, 1973