Correlation Between the Histological Changes and Glucose Intestinal Absorption Following a Single Dose of 5 Fluorouracil

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Abstract
The effect of an antimitotic drug on the digestive tract was studied in the rat’s small intestine perfused in vivo with solutions of varying glucose concentrations. The histological changes of the intestinal mucosa are correlated with the absorptive capacity for glucose. A reduction in cell population followed injection of 5 Fluorouracil; there is a linear correlation between the number of epithelial cells and the height of villous processus. The quantity of glucose absorbed is reduced during the intoxication, and is linked to the number of cells. The study of absorption kinetics shows a linear correlation between the maximal rate of absorption (Vmax) and the number of cells, but the Km is only modified during the period of maximum intoxication showing a cytotoxicity.

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