Enhancement of the fluorescence cancer diagnostic method of tissues using diffuse reflectance and the analysis of oxygenation state

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Abstract
We report on an analysis of diffuse reflectance spectra measured in conjunction with the fluorescence from normal human breast tissues and malignant breast tumors. The diffuse reflectance spectra from excised, air-equilibrated, human breast tissue samples show lower fractions of oxygenated hemoglobin and higher content of ferric (Fe3+) heme in malignant breast tumor samples than in normal breast tissues. Normal tissues are found to be easily deoxygenated and reoxygenated, but malignant tumors usually do not change their state as much. An analysis of tissue oxygenation parameters is discussed with respect to an enhancement of predictive power of fluorescence diagnostic method. The oxygenation state of tissues may be used as an additional marker in cancer diagnostics.

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