THE ARRANGEMENT OF PURINE AND PYRIMIDINE NUCLEOTIDES IN TOBACCO MOSAIC VIRUS NUCLEIC ACID

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Abstract
Information pertaining to th.e mode of arrangement of some of the purine and pyrimidine nucleotides in tobacco mosaic virus nucleic acid (TMV-NA) was obtained using nucleases such as pancreatic ribonuclease and micrococcal phos-phodiesterase. These results show that in addition to both the purine nucleotides and pyrimidine nucleotides occurring in clusters of 2 or more, they also exist singly alternating with each other. The latter type of arrangement appears not to be so frequent as the former. There is a definite regularity in the arrangement of both the purine and pyrimidine nucleotides in TMV-NA, suggesting that the arrangement is not of a random type. Products obtained by digestion of nucleic acids of TMV, HR and M strains, with pancreatic ribonuclease, revealed significant differences in the mode of arrangement of purine and pyrimidine nucleotides in each of these molecules. This information provides evidence that the genetic specificity of a nucleic acid resides in the arrangement of its components, namely the purine and pyrimidine nucleotides.

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