IMMUNOGLOBULIN-SYNTHESIS IN NUDE (NU/NU), NU/+ AND RECONSTITUTED NU-NU MICE INFECTED WITH A DEMYELINATING STRAIN OF SEMLIKI FOREST VIRUS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 47  (2) , 283-288
Abstract
Infections with the avirulent (A7/74) strain of Semliki forest virus which causes primary demyelination of the CNS in mice were studied further in nude athymic (nu/nu) mice and their immunocompetent (nu/+) litter mates to measure the production of Ig. This was done by radial immunodiffusion and enzyme-linked immunosorbent assays. Half the nude mice examined were able to synthesize specific IgG but at levels 1000-fold lower than their nu/+ littermates. The majority of nude mice reconstituted with spleen cells from nu/+ mice 1 day before infection with virus were able to synthesize specific IgG nearly as well as the nu/+ animals.