Inhibition by Ketotifen of Idiosyncratic Reactions to Aspirin
- 1 July 1980
- Vol. 35 (5) , 421-424
- https://doi.org/10.1111/j.1398-9995.1980.tb01788.x
Abstract
Ketotifen administered prior to aspirin offered protection against bronchoconstriction in 13 of 14 patients with aspirin-sensitive asthma. In 4 other subjects suffering from urticaria/angioedema following ingestion of aspirin-like drugs, pretreatment with ketotifen resulted in total prevention of the adverse reactions. A common pathogenetic mechanism may be operating in 2 distinct clinical patterns of idiosyncrasy to aspirin and other cyclo-oxygenase inhibitors. Ketotifen might find application in treatment of adverse reactions to aspirin.Keywords
This publication has 11 references indexed in Scilit:
- Inhibition of idiosyncratic reactions to aspirin in asthmatic patients by clemastine.Thorax, 1979
- EFFECTS OF MODULATORS OF ARACHIDONIC ACID METABOLISM ON THE SYNTHESIS AND RELEASE OF SLOW‐REACTING SUBSTANCE OF ANAPHYLAXISBritish Journal of Pharmacology, 1979
- The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator releaseProstaglandins, 1978
- Comparison between ketotifen and DSCG in bronchial challengeClinical and Experimental Allergy, 1978
- Inhibition of aspirin-induced bronchoconstriction by sodium cromoglycate inhalation.Thorax, 1977
- Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesisJournal of Allergy and Clinical Immunology, 1977
- Oral aspirin challenges in asthmatic patients: a study of plasma histamineClinical and Experimental Allergy, 1976
- The effect of sodium cromoglycate on analgesic‐induced asthmatic reactionsClinical and Experimental Allergy, 1976
- The effect of sodium cromoglycate in preventing aspirin induced bronchospasmClinical and Experimental Allergy, 1976
- Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients.BMJ, 1975