Separation of Beta Adrenoceptor Antagonist Enantiomers by High Resolution Capillary Gas Chromatography
- 1 November 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 16 (11) , 543-546
- https://doi.org/10.1093/chromsci/16.11.543
Abstract
The diastereoisomers of beta adrenoceptor antagonists have been separated by gas-liquid chromatography. Enantiomers were reacted with N-trifluoroacetyl-l-prolyl-chloride (TPC), N-heptafluorobutyryl-l-prolyl-chloride (HPC) and N,O-bis-(trimethylsilyl)trifluoroacetamide and separated on packed and glass open-tubular columns. Application of the procedure for quantitative determination of the enantiomers is discussed.This publication has 6 references indexed in Scilit:
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