Rectal aspirin--absorption and antipyretic effect.
Open Access
- 1 September 1979
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 54 (9) , 713-715
- https://doi.org/10.1136/adc.54.9.713
Abstract
Rectal acetylsalicylic acid was given to 14 children who had undergone open heart surgery. The effect on their temperatures was similar whether 15--30 or 30--50 mg/kg was given. Either dose was more effective than no treatment. The greatest fall in temperature occurred after 4 or 5 hours. Rectal aspirin in a triglyceride base is effective in lowering postoperative temperature. It should also be of use in treating other fevers. A dose of 20--25 mg/kg is suggested.This publication has 12 references indexed in Scilit:
- The Absorption of an N-Methylated Barbiturate and Acetyl Salicylic Acid from Different Suppository Masses.Acta Pharmacologica et Toxicologica, 2009
- Value of monitoring plasma salicylate levels in treating juvenile rheumatoid arthritis. Observations in 42 cases.Archives of Disease in Childhood, 1978
- Bioavailability of Aspirin from Commercial SuppositoriesJournal of Pharmaceutical Sciences, 1975
- BIOAVAILABILITY AND TOLERANCE STUDIES ON ACETYLSALICYLIC-ACID SUPPOSITORIES1975
- Rectal Absorption From Aspirin Suppositories in Children and AdultsPediatrics, 1974
- Study of antipyretic therapy in current useArchives of Disease in Childhood, 1973
- Salicylate Absorption from Rectal SuppositoriesJournal of Pharmaceutical Sciences, 1971
- Drug Absorption from the Rectum 111:Aspirin and Some Aspirin DerivativesJournal of Pharmaceutical Sciences, 1970
- THE ACUTE RECTAL TOXICITY OF ACETYLSALICYLIC ACIDCanadian Journal of Physiology and Pharmacology, 1966