The mechanical and biochemical effects of pentoxifylline on the perfused rat heart

1 September 1980

journal article
research article
Published by Springer Nature in Cellular and Molecular Life Sciences

Vol. 36 (9) , 1088-1090
https://doi.org/10.1007/bf01965986

Abstract

Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10⁻⁴ moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.

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