Vascular Endothelial Growth Factor -- Its Role in Retinal Vascular Proliferation

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Abstract
The blood vessels of the human retina do not normally grow after birth. All postnatal neovascularization in this tissue is therefore pathologic, arising as a complication of diseases such as diabetes, sickle cell disease, and retinal-vein occlusion. The new vessels lack the barrier function of the normal retinal circulation and permit extravascular leakage of blood components. Because of their extremely thin endothelium, these vessels are fragile and can easily rupture, causing hemorrhage into the vitreous cavity. New retinal vessels are surrounded by fibroblasts or glial cells that may proliferate extensively as the disease progresses. The tough, contractile bands and membranes . . .