METHYLERGOMETRINE (METHYLERGONOVINE) CONCENTRATIONS IN HUMAN-PLASMA AND URINE

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 16  (6) , 254-257
Abstract
There were no significant differences in the radioimmunologically determined plasma concentrations of methylergometrine, nor in its 32 h cumulative urinary excretion after a single 0.250 mg oral dose of Methergin or Myomergin. Peak plasma concentrations were obtained as early as 0.5 h after drug administration. Approximately 3% of the 0.250 mg oral dose was excreted in the urine during a period of 32 h. In 2 subjects, after a single 0.20 mg i.v. injection, the .beta. phase half-life in the plasma was 1.9 h. From the ratio of the area under the plasma curve after oral and i.v. administration in these 2 subjects, it was estimated that 64% and 63% of the oral dose reached the systemic circulation. No cumulation in the plasma was observed after repeated oral doses of 0.125 mg of methylergometrine given 3 times daily to the 2 subjects.