X chromosome inactivation: how human are mice?
- 1 July 2002
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 99 (1-4) , 30-35
- https://doi.org/10.1159/000071570
Abstract
Mammals perform dosage compensation of X-linked gene products between XY males and XX females by transcriptionally silencing all but one X chromosome per diploid cell, a process called X chromosome inactivation (XCI). XCI involves counting X chromosomes in a cell, random or imprinted choice of one X to remain active, initiation and spread of the inactivation signal in cis throughout the other X chromosomes, and maintenance of the inactive state of those X chromosomes during cell divisions thereafter. Most of what is known of the molecular mechanisms involved in the different steps of XCI has been studied in the mouse. In this review we compare XCI in mouse and human, and discuss how much of the murine data can be extrapolated to humans.Keywords
This publication has 41 references indexed in Scilit:
- DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsNature, 2002
- Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatinNature Genetics, 2001
- Human X Inactivation Center Induces Random X Chromosome Inactivation in Male Transgenic MiceGenomics, 1999
- Embryonic Stem Cell Lines Derived from Human BlastocystsScience, 1998
- VIVE LA DIFFÉRENCE: Males vs Females in Flies vs WormsAnnual Review of Genetics, 1996
- Requirement for Xist in X chromosome inactivationNature, 1996
- The human X-inactivation centre is not required for maintenance of X-chromosome inactivationNature, 1994
- Role for DNA methylation in genomic imprintingNature, 1993
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityPublished by Elsevier ,1992
- A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosomeNature, 1991