THE ANTIDIURETIC EFFECT OF INTRAVENOUS AND INTRACAROTID INFUSION OF CALCIUM CHLORIDE IN HYDRATED RATS

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Abstract
SUMMARY: Calcium chloride was infused intravenously as a slightly hypotonic solution into hydrated rats anaesthetized with ethanol and Inactin. Doses of 12–24 mg. Ca2+/kg. caused a transitory antidiuretic effect during which time antidiuretic material was excreted in the urine. Intracarotid infusion of calcium chloride towards the head produced a more pronounced effect than intravenous infusion of the same amount. The same doses of calcium chloride failed to have an antidiuretic effect in rats with diabetes insipidus. These findings are discussed in relation to the hypothesis of Douglas & Poisner that calcium ions play an essential role in the release of vasopressin from the posterior pituitary gland.