BIOTRANSFORMATION AND EXCRETION OF METHYLCYCLOPENTADIENYL MANGANESE TRICARBONYL IN THE RAT

  • 1 January 1980
    • journal article
    • research article
    • Vol. 8  (6) , 428-433
Abstract
Biotransformation and excretion of methylcyclopentadienyl manganese tricarbonyl (MMT) [in gasoline] was studied in vivo in the rat and in vitro using rat liver and lung microsomes. Orally administered 3H-MMT was efficiently absorbed, metabolized and excreted in urine as 2 major metabolites, (CO)3MnC5H4CO2H and (CO)3MnC5H4CH2OH, which accounted for 67% and 14% of urinary 3H, respectively. These metabolites were excreted in significant quantities in bile, but underwent reabsorption and excretion by kidney since only a small fraction of administered 3H appeared in feces. In vitro MMT was rapidly metabolized by a cytochrome P-450-dependent process inducible in liver but not in lung microsomes. In vivo induction by phenobarbital doubled the rate of biliary excretion of MMT metabolites, and protected the rat against toxic effects of MMT.

This publication has 1 reference indexed in Scilit: