Effects of Anterior Pituitary Preparations on Mammary Gland Growth in Mouse.

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Abstract
Mammogenic potencies of a number of crude and purified anterior pituitary fractions were determined by estimation of mammary gland desoxyribosenucleic acid (DNA) in treated ovariec-tomized mice. Crude bovine AP, initial residue (IR) obtained by depleting AP of known hormones, a newly developed mammogen extracted from IR (mammogen "C") and lactogenic preparation produced lobule-alveolar development. Extracted mammogen "C" was white, crystalline, apparently salt-free and water soluble. Crude and purified FSH and growth hormone exhibited little or no mammogenic effects when injected with a synergizing dose of estradiol benzoate in ovariectomized mouse.

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