Fat-deficiency disease of rats. The relation of the essential unsaturated acids to tumour formation in the albino rat on normal diet

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Abstract
Walker tumor tissue was implanted in rats of 100-150 g. wt., fed on a normal diet containing fish meal and oil cake. Large tumors developed in 10-14 days. The proportion of lipid substance to fat-free dry weight was detd. in skin, carcase and liver and compared with the corresponding values in the controls. The figures were very variable and no significant differences were established. The highly unsaturated acids were estimated as bromide insoluble in cold benzene and their ratio to the fat-free dry weight determined in skin, liver and carcase. In all the tumor-bearing animals, there was a marked fall in this ratio in the subcut. tissue when compared with the corresponding figures for the normal control rats. No such difference was detected in the carcase and liver fat. In the only expt. in which tumora failed to develop the controls showed abnormally low % ratio of highly unsaturated acid to the fat-free dry wt. of the tissue.