Intravenously Administered ACTH
- 24 May 1951
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 244 (21) , 796-798
- https://doi.org/10.1056/nejm195105242442104
Abstract
SAYERS and his co-workers1 demonstrated that large doses of ACTH administered intravenously over one half hour disappeared rapidly from the blood stream in two normal subjects, while giving rise to maximum but transient adrenal cortical stimulation. Gordon2 first drew attention to the fact that the administration of ACTH in a continuous intravenous drip led to sustained adrenal cortical stimulation in human subjects, and he emphasized that relatively small quantities of ACTH were required. This was identical with the experience of Ingle,3 who was able to produce greatly enlarged adrenal cortices in rats given small quantities of ACTH over a number . . .Keywords
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