AMELIORATION OF CISPLATIN-INDUCED NEPHROTOXICITY BY THE DIURETIC ACETAZOLAMIDE IN F344 RATS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 68  (7-8) , 999-1004
Abstract
Renal toxicity following a single i.v. nonlethal dose (6 mg/kg) of [the antineoplastic drug] cisplatin (CDDP) was investigated in male F344 rats pretreated with 20 mg/kg of acetazolamide (ACZ) s.c. 30 min before CDDP administration. There was a decrease in nephrotoxicity as indicated by a smaller elevation of BUN [blood urea nitrogen], a milder histopathologic lesion and a more rapid recovery of BUN in ACZ-pretreated animals. Renal Pt content of rats receiving ACZ was significantly lower than that in animals treated with CDDP alone. There was no change in Pt level in the plasma or the liver, but there was a decreased Pt excretion in urine during 24 h after treatment. Reduction of Pt concentration in the kidney might account for protection against the renal toxicity. The diuretic ACZ might be useful in the hydration regimens used clinically to prevent renal toxicity from CDDP.