Two Hydrolase Resistant Analogues of Diadenosine 5',5'''-P,P-Triphosphate for Studies with FHIT, The Human Fragile Histidine Triad Protein
- 1 January 1998
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 17 (1) , 301-308
- https://doi.org/10.1080/07328319808005178
Abstract
The design and synthesis of analogues of diadenosine 5′,5″′-P,P-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their rôle in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap3A binding/cleaving protein.Keywords
This publication has 12 references indexed in Scilit:
- Genetic, biochemical, and crystallographic characterization of Fhit–substrate complexes as the active signaling form of FhitProceedings of the National Academy of Sciences, 1998
- Structure and expression of the human FHIT gene in normal and tumor cells.1997
- The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract CancersCell, 1996
- Fhit, a Putative Tumor Suppressor in Humans, Is a Dinucleoside 5‘,5‘ ‘‘-P1,P3-Triphosphate HydrolaseBiochemistry, 1996
- Antithrombotic effect of beta,beta'-monochloromethylene diadenosine 5',5"'-P1,P4-tetraphosphate.Proceedings of the National Academy of Sciences, 1992
- Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate and thiophosphate analogues of P1, P4-bis(5′-adenosyl) tetraphosphateNucleic Acids Research, 1987
- The presence of diadenosine 5′,5‴-P 1 ,P 3 -triphosphate (Ap 3 A) in human plateletsBiochemical and Biophysical Research Communications, 1983
- Abundant amounts of diadenosine 5′,5‴-P1,P4-tetraphosphate are present and releasable, but metabolically inactive, in human plateletsBiochemical Journal, 1982
- Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-sRNA synthetaseBiochemical and Biophysical Research Communications, 1966
- The Occurrence of P1,P4-Diguanosine 5'-Tetraphosphate in Brine Shrimp EggsJournal of Biological Chemistry, 1963