Two Hydrolase Resistant Analogues of Diadenosine 5',5'''-P,P-Triphosphate for Studies with FHIT, The Human Fragile Histidine Triad Protein

Abstract
The design and synthesis of analogues of diadenosine 5′,5″′-P,P-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their rôle in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap3A binding/cleaving protein.

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