Reduction of stimulus-bound food consumption in the rat following amphetamine administration.

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Abstract
Studied the effects of intraperitoneal administration of dextroamphetamine on stimulus-bound food consumption in 30 male sated rats. Lateral hypothalamic stimulation which resulted in feeding was either programed to occur at regular intervals or delivered by the S's response (self-stimulation). Stimulus-bound food intake was reduced by dextroamphetamine, 3.0 or 4.0 mg/kg dosages being sufficient to cause almost complete anorexia. Reflexive sniffing and chewing of food and self-stimulation behaviors were unaffected. Results indicate that amphetamine selectively interacts with the adrenergic feeding system of the lateral hypothalamus to produce an inhibition of food consumption. (17 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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