EFFECT OF FUROSEMIDE ON FLOW AND COMPOSITION OF BILE IN DOG

  • 1 January 1977
    • journal article
    • research article
    • Vol. 144  (5) , 721-726
Abstract
The effect of furosemide, a potent inhibitor of active Na transport, on the amount and composition of bile was studied in the dog. Ten milligrams/kg of body weight of furosemide were injected i.v. to anesthetized dogs with a previously constructed fistula of the common bile duct. In all dogs, a 2.5 times increase in bile flow was observed concomitant with a 15 times increase in urinary output. The amount of bile flow decreased gradually and returned to control levels 60-75 min after furosemide injection. The choleretic effect was associated with a high increase in Na, Cl and bicarbonate anions and with a smaller increase in K, P and Ca. The total amount of bilirubin alkaline phosphatase and cholesterol was not significantly affected, while the calculated output of inorganic salts increased. Inhibition of Na reabsorption by furosemide appears to simultaneously affect the liver and kidney. The increase in electrolyte solution is most likely caused by the inhibition of Na reabsorption in the ductuli. Furosemide also may interfere with the Na mediated secretory fraction at the canalicular level, but the predominant factor determining the increase in bile flow and electrolytes is inhibition of Na reabsorption in the biliary ducts and ductuli.

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