2-Chloroadenosine inhibits brain acetylcholine turnover in vivo

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Abstract
Intracisternal administration of 2-chloroadenosine (10 μg) to rats inhibited the apparent turnover rate of acetylcholine in the hippocampus and cortex but not the striatum. The regional variation in this inhibition did not correlate with the apparent density of adenosine receptors as determined by receptor binding techniques. The results indicate that while purinergic mechanisms may be involved in the regulation of specific central cholinergic neurons, the physiological actions of the purine may not be unique to this transmitter system.

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