Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Monoclonal Antibodies, Immunotoxins or Antisense Oligodeoxynucleotides in Kidney Carcinoma and Normal Kidney Cells
- 1 January 1993
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 50 (4) , 303-308
- https://doi.org/10.1159/000227200
Abstract
In the present investigation we show that both monoclonal antibodies against P-170 (265/F4, MRK 16, and HYB612) and 265/F4-ricin alpha-chain immunotoxin are useful tools for the eradication of kidney carcinoma and normal kidney primary cell cultures with high P-170 expression, whereas kidney tumor and normal kidney cell lines with low amounts of P-170 are less affected. Furthermore, we found that the expression of P-170 in both kidney tumor and normal kidney cell cultures with high amounts of P-170 was inhibited by anti-sense oligodeoxynucleotides complementary to base pairs –9 to +6 of the MDR1 gene. These data indicate that these approaches for the eradication of P-170 expressing multidrug-resistant cells are not limited to tumors but also affect P-170 expressing normal cells.Keywords
This publication has 0 references indexed in Scilit: