Excitation-contraction in rat myocardium: alterations with adult aging

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Abstract
Simultaneous transmembrane action potential (TAP) and isomeric contraction measurements were made in thin right ventricular papillary muscles isolated from senescent (S, 24-26 mo.) and young adult (YA, 6-8 mo.) rat hearts. At the peak of the length-tension curve in the steady state at 24 min-1 at 29.degree. C in perfusate [Ca2+] ([Ca2+]e) of 0.375 or 2.5 mM, contractile tension developed in response to excitation (DT) and the maximum rate of tension development (dT/dt) were not age-related; contraction duration (CD) was 17 and 27% greater in S than YA in the low and high [Ca2+]e, respectively (P < 0.001); resting membrane potential was not age related. TAP time above zero mV, integrated area above zero mV and times to 75% (T75) and 90% (T90) repolarization were .apprx. 2-fold greater in S than in YA in both [Ca2+]e (P < 0.001). Changes in steady-state T75 and T90 due to an increase in [Ca2+]e from 0.375 to 2.5 mM were significantly correlated with those in CD, DT and dT/dt in S but not in YA. In the senescent myocardium a prolonged and greater extent of depolarization is related to the prolonged CD and may also be a determinant of the peak force developed in response to excitation under some conditions.

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