Elevation of Serum Angiotensin-Converting Enzyme Activity in Patients with Hyperthyroidism
- 1 November 1982
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 55 (5) , 931-934
- https://doi.org/10.1210/jcem-55-5-931
Abstract
The activity of serum angiotensin-converting enzyme (S-ACE) was determined spectrophotometrically in 45 patients with hyperthyroidism (30 untreated and 15 treated and euthyroid patients), 14 patients with hypothyroidism, and 135 normotensive healthy subjects. S-ACE was significantly higher in the patients with untreated hyperthyroidism (51.6 ± 1.9 < SE > nmol • min/ml) than in the healthy controls (28.6 ± 0.6 nmolmin/ ml; P < 0.001). On the other hand, S-ACE was found to be within the normal range in patients with hypothyroidism (23.2 ± 1.3 nmol-min/ml). In patients with hyperthyroidism, S-ACE gradually fell into the normal range as the thyroid function became normalized, and there were significant positive correlations between S-ACE and the plasma T3 or T4 concentration (r = 0.60 and P < 0.001; r = 0.61 and P < 0.001, respectively). SACE had no definite relation to blood pressure, serumglutamic oxaloacetic acid transaminase, or glutamic pyruvic acid transaminase. Whenthe physiochemical characteristics of the enzyme in the sera of hyperthyroidism patients were compared with those in sarcoidosis patients, similar peak activities of S-ACE on gel chromatography and identical Michaelis constants were obtained; the effects of ethyldiaminetetraacetic acid, SQ14225, and pH on the enzymatic reaction were also similar in both diseases. Thus, hyperthyroidism is considered to be one of the diseases in which S-ACE is elevated. The elevation of S-ACE might be directly or indirectly related to the hyperthyroid state. In addition, it is suggested that the enzyme characteristics are identical in hyperthyroidism and sarcoidosis. (J ClinEndocrinol Metab55: 931, 1982)Keywords
This publication has 11 references indexed in Scilit:
- Angiotensin-I-Converting Enzyme and Gallium Scan in Noninvasive Evaluation of SarcoidosisAnnals of Internal Medicine, 1979
- SERUM ANGIOTENSIN-CONVERTING ENZYME (SACE) IN SARCOIDOSIS AND OTHER GRANULOMATOUS DISORDERSThe Lancet, 1978
- Marked Elevation of Serum Angiotensin-converting Enzyme and Hepatic Fibrosis Containing Long-spacing Collagen Fibrils in Type 2 Acute Neuronopathic Gaucher’s DiseaseAmerican Journal of Clinical Pathology, 1978
- Serum Angiotensin-Converting Enzyme in Leprosy and CoccidioidomycosisAnnals of Internal Medicine, 1977
- Elevated serum and spleen angiotensin converting enzyme and serum lysozyme in Gaucher's diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1977
- SERUM ANGIOTENSIN CONVERTING ENZYME IN SARCOIDOSIS - CLINICAL SIGNIFICANCE1977
- INCREASED SERUM ANGIOTENSIN CONVERTING ENZYME-ACTIVITY IN SARCOIDOSIS1977
- Elevation of Serum Angiotensin-Converting Enzyme in Gaucher's DiseaseNew England Journal of Medicine, 1976
- ELEVATED SERUM ANGIOTENSIN-I CONVERTING ENZYME IN SARCOIDOSISPublished by Elsevier ,1976
- Kininase Activity in Human BloodThe Tohoku Journal of Experimental Medicine, 1966