Detection of Induced DNA Strand Breaks with Improved Sensitivity in Human Cells
- 1 March 1980
- journal article
- letter
- Published by JSTOR in Radiation Research
- Vol. 81 (3) , 492-495
- https://doi.org/10.2307/3575208
Abstract
When mixtures of 2 cell populations [human cervical carcinoma HeLa S3 cells] labeled with different radionuclides are tested with DNA unwinding technique, an accurate comparison with regard to DNA strand breaks can be made. In mixtures of irradiated and control cells, effects were detected by this technique down to a dose of 1 rad. This corresponds to 10-20 DNA single-strand breaks/cell, or less than 1 break/chromosome.This publication has 0 references indexed in Scilit: