Selective Hydrolysis of tRNA by Ethylenediamine Bound to a DNA Oligomer1
- 1 October 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 116 (4) , 719-720
- https://doi.org/10.1093/oxfordjournals.jbchem.a124586
Abstract
A sequence-selective artificial ribonuclease was prepared by attaching ethylenediamine to the 5‘-end of a DNA oligomer as the sequence-recognizing moiety. The hybrid, incorporating a 19-mer DNA which is complementary with the A44-A62 sequence of tRNAPhe, hydrolyzed the tRNA selectively at the 3’side of C63.Keywords
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