Redundant cell death mechanisms as relics and backups
Open Access
- 1 April 2005
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 12 (S2) , 1490-1496
- https://doi.org/10.1038/sj.cdd.4401607
Abstract
Here we review recent observations indicating the existence of redundant cell death mechanisms. We speculate that this redundancy reflects a particular evolutionary history for cellular demise. Autophagic or apoptotic elements might have been added to a primordial death mechanism, initially improving cell dismantling and later acquiring the ability to act themselves as death effectors. The resulting redundancy of cell death mechanisms has pathophysiological implications.Keywords
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