Infertility: Incidence of spontaneous abortion in clomiphene pregnancies

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Abstract
The purpose of this study was to determine whether the use of clomiphene results in a higher incidence of spontaneous abortion than occurs naturally in subfertile patients. Reproductive outcomes of 1744 clomiphene pregnancies were compared to outcomes of 3245 spontaneous pregnancies in a prospective study. Abortion was classified as clinical if a sac was seen on ultrasound or if it occurred after 6 gestational weeks, and as preclinical if a quantitative human chorionic gonadotrophin (HCG) was ≥ 25 mIU and no sac was seen or abortion occurred earlier. The overall incidence of abortion was higher for clomiphene pregnancies (23.7%), compared with spontaneous pregnancies (20.4%) (P P P P P <0.05). We conclude that the increase in abortion due to clomiphene is small and may be related to different causes for women aged <30 and ≥30 years, and also that clomiphene may decrease clinical abortions in patients with luteal insufficiency.

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