INHIBITION BY THE TETRAMINE DISULPHIDE, BENEXTRAMINE, OF CARDIAC CHRONOTROPIC HISTAMINE H2‐RECEPTOR‐MEDIATED EFFECTS
Open Access
- 1 April 1982
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 75 (4) , 573-578
- https://doi.org/10.1111/j.1476-5381.1982.tb09176.x
Abstract
1 Benextramine (N,N'-bis[o-methoxybenzylamino)-n-hexyl]cystamine), which irreversibly blocks α-adrenoceptors and does not inhibit the H1-receptor-mediated contractile effect of histamine on guinea-pig isolated ileum, also did not inhibit the H1-receptor-mediated inotropic effect of histamine on guinea-pig isolated atrium. 2 Benextramine irreversibly inhibited the H2-receptor-mediated chronotropic effect of histamine on guinea-pig isolated atrium. 3 Since its combination with the competitive H2-receptor blocking drug cimetidine had an additive blocking effect, benextramine appears to act directly on the chronotropic H2-receptor.Keywords
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