Metabolism of 4-Dimethylaminoazobenzene and Related Compounds. IV. Metabolites of o-Aminoazotoluene in Rat Bile.

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Abstract
Biliary metabolites of 0-aminoazotoluene (OAT), i.e. 4-amino-3,2''-dimethylazobenzene, were investigated in rat and identified as N-glucuronide of OAT, N-glucuronide of OAT-derivative whose 2''-methyl group was oxidized hydroxymethyl, conjugates of 4''-hydroxylated OAT with sulfuric acid or glucuronic acid, similar conjugates of 4''-hydroxylated and N-acetylated OAT, and a double conjugate of 4''-hydroxylated OAT with N-glucuronic acid and O-sulfuric acid. The method for determination of OAT-NG, a main metabolite, in which an internal standard substance was adopted to thin-layer chromatography, was examined and gave good results. Similar methods were also examined for determination of other minor metabolites.

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