Intrauterine Dystrophy in Rats Due to Placental Insufficiency Caused by Hormonally Induced Prolonged Gestation

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Abstract
The duration of pregnancy in rats can be prolonged beyond day 26 after conception by administration of synthetic gestagens. The fetal mortality increased with prolonged duration of gestation to 24.8% on day 24 and 54.6% on day 25. Nearly all the fetuses were dead on day 26. On day 24 some of the litter mates and on day 25 all of the living ones were markedly hypotrophic. A placental insufficiency is suggested as causing the increasing mortality and the hypotrophy of the fetuses. The placental weight increases up to the 20th day of gestation, decreases slightly thereafter and does so markedly beyond the 24th day. An increase of water content is characteristic for the postmature litter mates.

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