Effect of Human Growth Hormone on Hypoglycemic States

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Abstract
THE administration of small doses of purified preparations of human growth hormone to patients with diabetes mellitus may produce profound changes in the metabolism of carbohydrate, resulting in elevations in blood sugar and the appearance of ketoacidosis.1 2 3 It is of interest that despite the "anti-insulin" effects of human growth hormone, especially in hypophysectomized diabetic patients,4 , 5 small doses of this hormone have had little or no effect upon carbohydrate metabolism in normal subjects6 7 8 or in panhypopituitary dwarfs,9 but few studies have been carried out with human growth hormone in conditions of altered carbohydrate metabolism caused by conditions other than diabetes mellitus. . . .