The Radiotoxic Effects of S35in Growing Cartilage

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Abstract
With the availability of radioactive sulfate, many experiments have been conducted to enhance our biological concept of chondroitin sulfate. It has been shown that the radioactive sulfur of labeled sulfate given to rats is incorporated into chondroitin sulfate and fixed in cartilage (1, 2). It is known that differentiated tumors have a metabolic pattern similar to their tissue of origin. The uptake of S35 by tissue cultures of human cartilage and tumors was studied by Layton (3) to confirm the cartilaginous nature of the growths by in vitro studies. Observations on the uptake of sulfate in human chondrosarcoma in vivo appear to be limited to the two cases studied by Gottschalk (4). He found that S35 was retained at high levels in both primary and metastatic chondrosarcoma, with lesser amounts in the normal cartilage, bone marrow, and other tissues. His autoradiographs indicate maximum concentration in the growing portions of the chondrosarcoma and in the areas containing abundant ground substance. Since t...

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