Mitomycin C-induced mosaicism in C-band regions of human chromosomes 1, 9, 16, and Y

1 July 1985

journal article
research article
Published by Springer Nature in Human Genetics

Vol. 70 (3) , 243-245
https://doi.org/10.1007/bf00273449

Abstract

In order to test the hypothesis that somatic mosaicism involving C-band polymorphism of human chromosomes 1, 9, 16 may arise from mitotic crossing over, peripheral blood lymphocytes from normal males were treated with mitomycin C, which is known to induce somatic crossing over in lower eukaryotes. Evidence is presented which shows that mitomycin C is able to alter the heterochromatic pattern in human lymphocytes.

Keywords

POLYMORPHISM

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