Numerous articles demonstrating the feasibility of the surgical removal of the duodenum and the head of the pancreas for carcinoma involving one or both of these organs have appeared in the surgical literature since Whipple1 reported the successful extirpation of the head of the pancreas in 1938. Colectomy of the right side in either one or two stages, for malignant lesions involving the cecum, ascending colon or hepatic flexure, is a well recognized surgical procedure which carries a relatively low mortality rate. The cases reported in this communication are of interest because they present instances of primary carcinoma of the proximal portion of the transverse colon which had eroded the second portion of the duodenum, producing a large fistulous opening between the two lumens of the bowel. Removal required colectomy of the right side and in addition necessitated the carrying out of the Whipple type of operation for carcinoma