THE INFLUENCE OF PROGRESSIVE TOXEMIC LIVER DAMAGE UPON THE DEXTROSE TOLERANCE CURVE

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Abstract
Exps. on dogs showed that the sequence of dextrose tolerance curves obtained by repeated tests during a progressively increasing toxemic liver damage is related to the nature and degree of the interference with the homeostatic mechanism by which the liver normally decreases its output of blood sugar in response to the influx of exogenous sugar. The cycle of events following the onset of the toxemia depends on the amt. of sugar used for the test. It is not a progression from the normal to increasingly abnormal curve, but passes from the normal to the "diabetic" type, then back to the normal, and again to the abnormal, which may now be either "supernormal" or markedly "diabetic." The relation of these results to the interpretation of the dextrose tolerance test is briefly discussed.

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