How might cohesin hold sister chromatids together?
- 29 March 2005
- journal article
- review article
- Published by The Royal Society in Philosophical Transactions Of The Royal Society B-Biological Sciences
- Vol. 360 (1455) , 483-496
- https://doi.org/10.1098/rstb.2004.1604
Abstract
The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.Keywords
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