Influence of Bestatin, a New Immunomodulator, on Ig Secretion by Human Lymphocytes in vitro and in vivo
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 64 (3) , 338-344
- https://doi.org/10.1159/000232712
Abstract
Bestatin, a chemically well-defined immunomodulator, was tested for its capacity to interfere with PWM-induced Ig synthesis of peripheral lymphocytes from healthy donors. It was observed that secretion of IgA, IgG and IgM was impaired when Bestatin was present in the cultures. Serum Ig concentrations and antibody activities of IgG class to cytomegalovirus, herpes simplex and morbilli virus were examined in cancer patients who were treated with 30 mg of Bestatin daily for 1–21 weeks. These values remained constant during Bestatin treatment indicating that antibody secretion in vivo was not affected.This publication has 7 references indexed in Scilit:
- RESTORATION OF IMPAIRED IMMUNE FUNCTIONS OF AGED ANIMALS BY CHRONIC BESTATIN TREATMENT1979
- Solid-phase enzyme immunoassay for immunoglobulin M antibodies to cytomegalovirusJournal of Clinical Microbiology, 1977
- Solid-phase radioimmunoassay of human immunoglobulin M and immunoglobulin G antibodies against herpes simplex virus type 1 capsid, envelope, and excreted antigensInfection and Immunity, 1977
- A Solid-Phase Radioimmunoassay for IgG and IgM Antibodies Against Measles VirusJournal of General Virology, 1977
- Aminopeptidase activities on the surface of mammalian cellsBiochimica et Biophysica Acta (BBA) - Enzymology, 1976
- ENZYME IMMUNOASSAYS IN DIAGNOSTIC MEDICINE - THEORY AND PRACTICE1976
- Enhancement of delayed-type hypersensitivity by bestatin, an inhibitor of aminopeptidase B and leucine aminopeptidase.The Journal of Antibiotics, 1976