Neutralization of reovirus: the gene responsible for the neutralization antigen.
Open Access
- 1 November 1977
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 146 (5) , 1305-1310
- https://doi.org/10.1084/jem.146.5.1305
Abstract
The S1 genome segment of reovirus is linked to type specificity as determined by neutralization antibody. This gene segment codes for a minor outer capsid polypeptide (sigma1). Therefore, sigma1 is the peptide responsible for induction of neutralization antibody and confers type specificity. This biologic property of reovirus was defined using hybrid recombinants clones between reovirus types 1 and 3 and 2 and 3.Keywords
This publication has 16 references indexed in Scilit:
- REOVIRUSES IN ANIMALS OTHER THAN MANAnnals of the New York Academy of Sciences, 2006
- Antigenic determinants of adenovirus capsids. II. Homogeneity of hexons, and accessibility of their determinants, in the virion.1976
- Antigenic determinants of adenovirus capsids. I. Measurement of antibody cross-reactivity.1976
- Effect of specific antibodies on biological functions of the envelope components of Newcastle disease virusVirology, 1974
- Studies on the effect of chymotrypsin on reovirionsVirology, 1972
- Viral RNA Polymerases: Electron Microscopy of Reovirus Reaction CoresScience, 1971
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970
- Polypeptide components of virions, top component and cores of reovirus type 3Virology, 1969
- Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirusVirology, 1969
- Identification in a recombinant influenza virus of structural proteins derived from both parentsVirology, 1966