Cycloheximide blocks changes in rat liver carnitine palmitoyltransferase 1 activity in starvation
- 15 November 1984
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 224 (1) , 201-206
- https://doi.org/10.1042/bj2240201
Abstract
Starvation (24h) increased the maximum activity of carnitine palmitoyltransferase 1 in rat liver and increased the concentration of malonyl-CoA required to cause 50% inhibition of the enzyme (I50). Re-feeding (24h) with a standard cube diet or a high-carbohydrate diet reversed both of these changes, whereas re-feeding with a high-fat diet did not. Administration of cycloheximide (200 micrograms/100 g body wt.) blocked the increases in carnitine palmitoyltransferase 1 activity and I50 on starvation. It is suggested that increase in carnitine palmitoyltransferase 1 activity in starvation may involve synthesis of new enzyme.This publication has 23 references indexed in Scilit:
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