Attentional deficits in Long-term survivors of childhood acute lymphoblastic leukemia (ALL)

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Abstract
Simple alerted auditory reaction time (SRT) behavior with various foreperiods was investigated in a group of long-term survivors of childhood ALL [acute lymphoblastic leukemia] who were in continuous 1st remission. As part of therapy, the patients had received cranial irradiation and intrathecal chemotherapy to prevent the development of CNS leukemia. The patients were divided into 3 groups on the basis of [computed tomography] brain scan findings: those with normal CT scans (n = 10); those with evidence of cortical atrophy (n = 8) and those with intracerebral calcifications (n = 5). The SRT results indicated significant differences between patients with normal and abnormal CT scans. Specifically, patients with abnormal scans reacted slower and this latency was exaggerated by increasing the length of the warning interval. They reacted with larger variability which increased with the prolongation of testing. The severity of impairment was related to the type of CT-scan abnormality; patients with calcifications performed more poorly than patients with evidence of atrophy. A strong correlation was revealed between the presence and type of CT-scan abnormalities and attentional performance in long-term survivors of childhood ALL.