INDUCTION OF LACTATION IN HEIFERS BY A SINGLE INJECTION OF ESTERS OF DIETHYLSTILBOESTROL

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Abstract
The preceding papers in this series have dealt with the induction of lactation in heifers by the implantation [Folley & Malpress, 1944a; Hammond & Day, 1944] or feeding [Folley & Malpress, 1944b] of diethylstilboestrol. Both of these methods have disadvantages. Implantation of tablets, though apparently the most effective method, involves a minor surgical operation, a repetition of which may be necessary if the remains of the tablets have to be removed. Oral administration, on the other hand, requires very large dosage and, for some reason, is not very effective. It seems certain that a duration of treatment of not less than several weeks is required to produce the mammary changes leading to lactation, but there is no apparent reason why repeated injection should not produce the required result. Positive results with such a technique have in fact been obtained in various experiments on heifers [e.g. Walker & Stanley,

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