Identification of Hepatitis C Virus Genotypes among Hospitalized Patients in British Columbia, Canada

1 April 1995

journal article
Published by Oxford University Press (OUP) in The Journal of Infectious Diseases

Vol. 171 (4) , 1034-1038
https://doi.org/10.1093/infdis/171.4.1034

Abstract

The distribution pattern of hepatitis C virus (HCV) genotypes among patients from British Columbia has been investigated by reverse transcription polymerase chain reaction (PCR) amplification of the 5′ noncoding region (NCR) and direct DNA sequencing of the PCR product. The sequence data obtained from the British Columbia isolates were compared with HCV sequences for the NCR obtained from GenBank for the construction of a phylogenetic tree using the GDE program, version 2.2. The data show that in British Columbia there are 7 subtypes distributed among major genotypes 1, 2, and 3. The study also shows a new subtype of genotype 1 that represents 29% of the analyzed cases.

Keywords

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